Please enable JavaScript.

Coggle requires JavaScript to display documents.

Introduction to CNS Pharmacology, Transmitter, Reference:Katzung Made by…

- - - - Receptor:Alpha2; activated by clonidine
        
        Inhibitory (presynaptic); ↓ Ca2+ conductance
        
        Inhibitory (postsynaptic); ↑ K+
        
        conductance;cAMP
      - Receptor:Beta1; blocked by propranolol
        
        Excitatory; ↓ K+
        
        conductance; ↑ cAMP
      - Receptor:Alpha1; blocked by prazosin
        
        Excitatory; ↓ K+
        
        conductance; ↑ IP3 and DAG
      - Receptor:Beta2; blocked by propranolol
        
        Inhibitory; ↑ electrogenic sodium pump
- - - - Receptor:Single subtype; blocked by strychnine
        
        Inhibitory; ↑ Cl–
        
        conductance
- - - - Supraspinal interneurons
        
        Receptor:GABAA; facilitated by benzodiazepines and zolpidem
        
        Inhibitory; ↑ Cl–
        
        conductance
        
        Receptor:GABAB; activated by baclofen
        
        Inhibitory (presynaptic); ↓ Ca2+ conductance
        
        Inhibitory (postsynaptic); ↑ K+
        
        conductance
- - - - Receptor:Muscarinic, M1; blocked by pirenzepine and atropine
        
        Excitatory; ↓ K+
        
        conductance; ↑ IP3 and DAG
      - Receptor:Muscarinic, M2; blocked by atropine
        
        Inhibitory; ↑ K+
        
        conductance; ↓ cAMP
    - - Receptor:Nicotinic, N
        
        Excitatory; ↑ cation conductance
- - - - Receptor:D1; blocked by phenothiazines
        
        Inhibitory; ↑cAMP
      - Receptor:D2; blocked by phenothiazines and haloperidol
        
        Inhibitory (presynaptic); ↓ Ca2+ conductance;
        
        Inhibitory (postsynaptic); ↑ K+
        
        conductance;cAMP
- - - - Receptor:Alpha2; activated by clonidine
        
        Inhibitory (postsynaptic); ↑ K+
        
        conductance;cAMP
        
        Excitatory; ↓ K+
        
        conductance; ↑ IP3 and DAG
      - Receptor:Beta1; blocked by propranolol
        
        Excitatory; ↓ K+
        
        conductance; ↑ cAMP
      - Receptor:Alpha1; blocked by prazosin
        
        Excitatory; ↓ K+
        
        conductance; ↑ IP3 and DAG
      - Receptor:Beta2; blocked by propranolol
        
        Inhibitory; ↑ electrogenic sodium pump
- - - - Receptor:5-HT1A; buspirone is a partial agonist
        
        Inhibitory; ↑ K+
        
        conductance
      - Receptor:5-HT2A; blocked by clozapine, risperidone, and olanzapine
        
        Excitatory; ↓ K+
        
        conductance; ↑ IP3 and DAG
      - Receptor:5-HT3; blocked by ondansetron
        
        Excitatory; ↑ cation conductance
      - Receptor:5-HT4
        
        Excitatory; ↓ K+
        
        conductance; ↑ cAMP
- - - - Receptor:Four subtypes; NMDA subtype
        blocked by phencyclidine, ketamine, and memantine
        
        Excitatory; ↑ Ca2+ or cation conductance
      - Receptor:Metabotropic subtypes
        
        Excitatory (postsynaptic); ↓ K+
        
        conductance; ↑
        
        P3
        
        and DAG
        
        Inhibitory (presynaptic); ↓ Ca2+ conductance; ↓cAMP
- - - - Three major subtypes: µ, δ, κ
        
        Inhibitory (presynaptic); ↓ Ca2+ conductance;
        ↓cAMP
        
        Inhibitory (postsynaptic); ↑ K+conductance;↓cAMP