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Hashimoto's Disease, References:
Hashimoto thyroiditis: MedlinePlus…
Hashimoto's Disease
Pathogenesis
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• Autoimmune disease where the body destroys the thyroid cells and the antibody-mediated immune processes
o People will develop antibodies to the thyroid antigens, such as anti-thyroid peroxidase, antithyroglobulin and TSH receptor blocking antibodies
o This set of antibodies will attack the affected persons thyroid tissue which leads to inadequate production of thyroid hormone
• Early during the destruction of the thyroid cells, the person may exhibit signs and symptoms of hyperthyroidism because the destruction of the cells may be intermittent
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Risk Factors
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• Higher risk for developing Hashimoto’s disease if your family heredity has thyroid or other autoimmune diseases
• Having a different type of autoimmune disease such as rheumatoid arthritis or type one diabetes may increase your chances of developing Hashimoto’s disease
• Also people who have been exposed to extreme amounts of environmental radiation may develop the disease
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Treatments
• Other types of synthetic thyroid hormone are also available such as liothyronine sodium and liotrix
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• Also avoid foods high in grains, sodium, and iodine
• Use of synthetic hormone levothyroxine, which is identical to the natural version of the hormone thyroxine
o With this synthetic hormone your doctor will continually monitor your thyroid hormone and thyroid stimulating hormone levels to see how the dosage is affecting the patient
o Based on the hormone levels the doctor will either continue the oral dose or alter it by increasing or decreasing the dosage amount
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o Even after the doctor has found the right dosage for the patient, they will check the thyroid related hormone levels about once a year
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Clinical Manifestations
• The thyroid will be enlarged, often called a goiter
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