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Hepatitis C, Sources, David Towell - Coggle Diagram

- - - - Sofosbuvir belongs to the drug class Nucleotide HCV NS5B Polymerase Inhibitors and suppresses viral replication by inhibiting HCV NS5B RNA polymerase.
      - Velpatasvir is of the HCV NS5A Replication Complex Inhibitors and is a pangenotypic inhibitor of the NS5A protein that is required for Hep C viral replication.
      - Side effects include rash, diarrhea, irritability, and feelings of depression.
    - - Glecaprevir is a HCV NS53/4A Protease Inhibitor, inhibiting the enzyme that is required for the cleavage of the HCV-encoded polyprotein and is essential for viral replication.
      - Pibrentasvir belongs to the HCV NS5A Inhibitor drug class, and works by inhibiting the HCV NS5A protein essential for viral DNA replication and virion assembly.
      - Side effects for this drug include headache, fatigue, nausea, diarrhea, and pruritus.
    - - Elbasvir is another HCV NS5A Inhibitor, suppressing viral RNA replication and virion assembly
      - Grazoprevir is a HCV Protease Inhibitor that works similar to Glecaprevir, inhibiting proteolytic cleavage of HCV encoded polyproteins that are essential for viral replication
      - Side effects include fatigue, headache, abdominal pain, diarrhea, irritability, and depression