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Lymphatic System - Coggle Diagram

- - - - Cortex
        
        Outer cortex
        
        Inactivated B cells/follicles
        
        When activated may become a germinal centre
        
        Inner or paracortex
        
        T cells
      - Medulla
        
        Large blood vessels
        
        Medullary sinus
        
        Medullary cords
        
        Ab-secreting plasma cells
      - Hilum
        
        Efferent lymphatic vesels
        
        Lymphatic artery + vein
- - - - Blood vessels
      - Adipose cells
    - - Cortex + medulla
        
        Thymic reticular cells
        
        Thymic/Hassal's corpuscles
        
        Adipose cells
      - Medulla continues between lobules
    - - Secretory granules
        
        Thymic hormones
      - Involved in blood-thymus barrier
        
        Contact of immature T cells + foreign Ag's would cause T cells to die by apoptosis
    - - Function unclear
      - Involuted by puberty
      - In medulla
      - Formed from dysfunctional epithelial reticular cells
        
        Arranged concentrically
      - Keratin positive in stain
      - Lack nuclei
- - - - Survive
        
        Further training
      - 95% percent of entering T cells make it through
- - - - Including trabecular arteries + veins
    - - Active immune response
      - Lymphoid follicles (rich in B lymphocytes)
      - Periarteriolar lymphoid sheaths (PALS - rich in T lymphocytes)
    - - Filtration of RBCs
      - Sinuses (sinusoids)
      - Splenic cords
      - Marginal zone
        
        Between red + white pulp
      - Functions
        
        Removal of old RBCs
        
        Storage of RBCs + lymphocytes
        
        Produces all types of blood cell
        
        Only in foetus
- - - - Moncytes
        
        Tissue specific macrophages
        
        Kupffer cells (liver)
        
        Microglia cells (brain)
        
        Reticular cells (lymphoid tissues)
        
        Alveolar macrophages (lungs)
        
        Histiocytes (subcutaneous tissue)