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Critically evaluate the methodology, References - Coggle Diagram

- - - - Therefore this suits jeurissen et al study their study looked at the front part of the brain - used the right methodology
- - - - As a result of this ion flow, action potentials are triggered in neurons that are within the induced current field, along with a subsequent period of deactivation, presumably through prolonged IPSPs.
        
        Because normal ongoing brain activity is disrupted by this induced current, TMS provides a way for investigators to produce a transient and reversible period of brain disruption or “virtual lesion.”
  - - - The TMS - evoked neuronal activity leads to hemodynamic changes, as microvessals carry more oxygenated blood to the active area, the peak of these alterations occring a few seconds postimulus
  - - - The induced magnetic Weld (which is
        
        responsible for inducing current in the brain) is inversely
        
        proportional to the square of the distance between coil and
        
        cortex (Ilmoniemi et al. 1999; Wagner et al. 2007). Direct
        
        eVects of stimulation are therefore more or less restricted to
        
        the cortex close to the outer convexity of the brain. The
        
        concomitant stimulation of the scalp is painless, and in
        
        most cases TMS can therefore be applied without problems
        
        even in patients.
- - - - They found throughout the rTMS session, Ti temperatured was recorded with a thermocouple for subsequent analysis. Temperature was measured with a sampling rate equal to 0.25 Hz..
        
        Limited testing to 1 Hz trains, the upper limit of low frequency simulation with the assumption that lower frequencies would resul;t on less heating than 1 Hz trains
        
        Peak temperatures were reached within 900s of stimulation - therefore temperatures reached equilibrium.
        
        Temperatures did not increase appreciably
        
        after the first 900 s of recording (Fig. 1c), likely due to cooling between pulses and heating, caused by induced eddy
        
        currents, reaching equilibrium.
  - - - It is not possible to specifically target subcortical regions without affecting corticol ones because the strength of the time - varying magnetic field follows the inverse square law