Please enable JavaScript.
Coggle requires JavaScript to display documents.
Drugs Acting on the Uterus - Coggle Diagram
Drugs Acting on the Uterus
can be
Oxytocics
stimulate the
used to induce
drug classes include
Oxytocin
examples of drugs in this class are
Oxytocin
Carbetocin
synthesized in the
Hypothalamus
released from the
Posterior Pituitary
in response to
Stretching of the cervix
how does this compare to a
1 more item...
acts as agonist at oxytocin receptors on the
structurally similar to
Vasopressin
contrindications include
Labour that is progressing normally, abnormal fetal presentation, or fetal distress
also used to treat and prevent
Post-partum hemorrhage
Prostaglandins
examples of drugs in this class are
Misoprostol
adverse effects include
Fever
Dinoprostone
Carboprost
adverse effects include
Bronchospasm
Chest pain, hypertension, palpitations
may cause
GI Upset
work by
contracting the uterus
Relaxing the cervix
Ergot Alkaloids
cause
Spastic and prolonged uterine contractions
Might be
Uncomfortable for the patient
Increased blood pressure from vasoconstriction
used to treat
Post-partum hemorrhage
contraindications include
Hypertension, angina, and other CV risk factors
examples of drugs in this class are
Ergonovine
Methylergonovine
can be
Tocolytics
relax the
Uterus
used to stop or delay
Labour
drug classes include
Oxytocin Receptor Agonists
blocks oxytocin's effects on the
example of drug in this class is
Atosiban
which is not approved in
Canada
can also block vasopressin which may lead to
Hypotension
B2-receptor Agonists
relax uterine smooth muscle by
Inactivating MLCK
Binding to B2-receptors on myometrium
examples of drugs in this class are
Terbutaline (used off-label)
Ritrodine (approved in Canada then withdrawn)
adverse effects include
Tachycardia, nervousness, tremor
Calcium Channel Blockers
example of drug in this class is
Nifedipine
also used to treat
Hypertension
role is to
slow/stop contractions
adverse effects include
Hypotension and dizziness
Prostaglandin Synthesis Inhibitors
example of a drug in this class is
Indomethacin
which is an
NSAID
blocks production of
Prostaglandins
adverse effects include
Premature closure of ductus arteriosus
contraindicated if
Pregnancy <30-32 weeks
could also effect
Other areas of the body because prostaglandins are in almost every tissue
act on the
Myometrium
is made up of
Smooth Muscle
that contracts when there is an
Influx of calcium
makes me wonder if
Older pregnant people have less contractibility of the uterine smooth muscles
is the middle layer of the
Uterus
and cervix are innervated by
T10-L1, S2-S4