Massive systemic inflammatory response, and inflammation triggers cytokine release which will lead to fever, nausea and vomiting (general signs of inflammation), inflamed pancreas irritate adjacent intestines causing ileus which will lead to diminished bowel sounds, inflamed, so more permeable blood vessels leak fluid into pancreas, which will lead to profound dehydration ( flat JVP, hypotension, tachycardia, oliguria) might happen.