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Systemic Lupus Erythematosus, environmental is usually the initial trigger…

- - - - Antigens (nuclear material) are picked up by antigen-presenting cells, through toll-like receptors
        
        the antigens are then presented on the antigen-presenting cells surface, where the it will then travel to the lymph nodes
        
        Antigen-presenting cell then presents itself to an immature T-cell, where it comes activated
        
        IL4 Interleukin is secreted
        
        Favors T-Helper 2 cell maturation
        
        Promotes Humoral immune response
        
        B-Cell activation
        
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- - - - Hypertension occurs due renal failure
- - - - inhibiting interlukin 2 production and function, which prevents Helper T Cell Activity
    - - will reduce the lymphocyte activity (B-cells and T-cells)
        
        reduce the number of auto-antibodies produced
    - - monoclonal antibody, blocks the B lymphocyte stimulator
        
        inhibits production of auto-antibodies in B-Cells
    - - will suppress immune system and inflammation