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In vivo Study - Coggle Diagram
In vivo Study
Study Part I :silhouettes: :check:
Jan 2021
1.Proof of concept : NDs vaporization in vivo
2.Organs : vein, artery, kidney
3.First blood PK by vaporization (cBR38)
5.Formulatation tested :
NDs-C5F12 : No vaporization
cBR38 std : Slight increase of ADV threshold (In vivo : 1.1 x in vitro)
6.Various acoustic device tested
4.T1/2: 12.4±4.2 min (dose effect on T1/2)
7.Report -
Jan 2021
Study Part II :silhouettes: :checkered_flag:
March 2021
2.Blood PK :check:
Vaporization
Fluorescence
C4F10 dosage
1.Four formulations :check:
cBR38 std / NA4416
cBR38 Tx / ND2020
cBR38-DiR / BG9301
cNDs-Cy5.5 / BG8568
3.By vaporization :check:
T1/2: 10.7±2.8 min
No effect of various concentration and doses tested
Vaporization into organs after 1h (spleen, liver, kidney)
4.By fluorescence :check:
Significant blood fluorescence up to 6 hour
Du to circulating liposomes
5.By C4F10 dosage :check:
40% C4F10 found 3 min
GC-FID no enough sensitive
6.Report :pen: :checkered_flag:
March 2021
Study Part IV :silhouettes: :checkered_flag:
June 2021
Animal experiments authorization :check:
Feb 2021
Part 1: Evaluation of the NDs circulation and accumulation in the different organs - DATE
Part 2 : Evaluation of the NDs vaporization in the extravascular compartment and evaluation of US parameters - DATE
Part 3 : Evaluation of the vaporization of NDs in the extravascular compartment in pathological conditions - DATE
Article :question: - DATE
Plan the in vivo study -
March 2021
Study Part III :silhouettes: :checkered_flag:
March 2021
1.Blood PK
By fluorescence
By C4F10 dosage (Collab Unige) :silhouettes:
2.Formulation : cBR38-Cy5.5 / BG9321 :check:
Jan 2021
3.By fluorescence :checkered_flag:
March 2021
T1/2 > 20 min :question:
Organs accumulation
4.By C4F10 dosage :checkered_flag:
March 2021
Development method
Standard
Blood samples
Report :pencil2:
Study Part V :silhouettes: - DATE
1.Thermal ablation (plan a meeting) - DATE
2.Neuromodulation (plan a meeting) - DATE
4.Super resolution imaging - DATE
3.MRI - DATE