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Osteoarthritis - Coggle Diagram

- - - - synovial membrane
      - pathways
        
        prostaglandins
        
        leukotrienes
      - :arrow_down: Tissue Inhibitors of Metalloproteinases
      - :arrow_up:
        
        matrix metalloproteinases
        
        WBCs
  - - - primary/idiopathic
      - secondary
    - - non-infectious
        
        erosive
        
        non-erosive
      - infectious
- - - - NSAIDS
        
        COX-I
        
        COX-II
        
        contraindications
        
        vomiting/diarrhea/appetite loss
        
        concurrent steroids or aspirins
        
        going outside of recommended dose
        
        GI comorbidites
        
        history of ...
        
        renal disease
        
        hepatic disease
        
        glaucoma
        
        dehydration
        
        pregnancy
        
        hypotension
        
        coagulopathy
      - analgesia
      - weight loss
      - omega-3FA supplements
      - exercise modification
    - - biologicals
      - shockwave
      - adequan
    - - nutraceuticals
      - pretty much anything else claiming to work
- - - - lubricated by high viscosity hyaluronic acid
    - - avascular
      - anaerobic
      - layers
        
        superficial/gliding zone
        
        intermediate/transitional zone
        
        deep/radial zone
        
        tidemark
        
        subchondral bone
      - components
        
        chondrocytes
        
        secrete
        
        proteoglycan aggregates
        
        collagenous fibers
        
        proteoglycans
        
        core proteins
        
        glycosaminoglycans
        
        2 more items...
        
        big responsibilities
        
        stability of matrix
        
        1 more item...
        
        volume definition of matrix
        
        1 more item...
        
        mechanical properties
        
        collagen