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Membrane receptor-mediated and nuclear receptor mediated signal…
Membrane receptor-mediated and nuclear receptor mediated signal transduction
Nuclear
Ligand modulated transcription regulators
Hydrophobic signals ( Steroid hormons,Thyroid hormones, retinoids,vitamin D)
Receptors
In the cytosol ( cortisol)
ligand binding
enter the nucleus
Trascription
In the nucleus (thyroid and retinoid) (always bound to DNA)
orphan nuclear receptors
.
membrane
Hydrophilic ligand
Perfor signal transduction
Receptors
GPCR
Enzyme-linked receptors
Ion channels
Mechanically gated
ligand gated
Voltage-gated
DNA binding domains
ERE (estrogen response element)
GRE (glucocorticoid)
VD3RE