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Extended Essay Initial Brainstorming - Coggle Diagram

- - - - E.g. Taxol, Vinblastine, ATIs can be used as inhibitors (need to think of how to access/order inhibitors)
        
        Could compare results on hemocytometer (often used in hospitals to analyse cells/tissue/blood) and spectrophotometer (more analytical, would measure cell count indirectly by measuring amount of light transmitted
        
        Need to check if hemocytometer is available, if school spectrophotometer can measure negative values (as would be expected from fewer cells, if blank solution is normal cell culture)
        
        Experiment could be very novel, many different ways to approach -- 1 inhibitor could be used for each stage of the cell cycle (e.g. tubulin stabilisation/destabilisation, CDK inhibitors, DNA synthesis inhibitors).
      - Could use fission yeast as the cell culture, very fast (only 2-4 hours for replication when eukaryotic cells, e.g. human ones, take about 24 hours to divide). Also a good standard that is easily grown in labs and used for genetics experiments
        
        would need to check if science dept. has access to this
    - - however issue with ethics in mitogenic factors, can be very dangerous to handle (e.g. AG 1748 can cause severe damage to endocrine system)
  - - - Effects of Metals?
        
        E.g. Copper, Zinc, Magnesium
      - Effects of traditional medicine (e.g. ayurveda?)
        
        E,g, Tulsi Leaves, cardamom spices
- - - - Could look into Sickle Cell Anemia, Haemophilia (diseases that have already been treated this way in 2014)
    - - Experiment on shelf life of GMO tomatoes (activity of GM polygalactonurase activity), compare to normal tomatoes to show effects of GMOs on half-life, making suppliers more responsive to demand changes......although would be hard to get GMO/organic vegetables
    - - Could look at how land is being saved, how minerals are fed into plants through hydroponics and how effective it is....
    - - Could do an experiment showing the changes in mitotic index after being exposed to about 1 week's worth of microwave radiation (source could be from electronic devices or artificially induced through other means,