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MODEL ORGANISMS & CELL CULTURES for the DEVELOPMENT of NEW THERAPIES -…
MODEL ORGANISMS & CELL CULTURES for the DEVELOPMENT of NEW THERAPIES
CELL CULTURES
primary
growth rate
secondary
finite cell line
transformed cells
immortalized
chemically induced
virally induced
spontaneously
tumorigenicity assay
He-La cells
cancerous
grow unusually fast
immortal
bioethical issues
REGENERATIVE MEDICINE
nerve regeneration
Stem Cell Therapy
burn care
HYBRIDOMA CELL LINE
human mAb
produced ex vivo
different from animal pAb
B lymphocytes of the spleen
+
immortal myeloma cells
VACCINE PRODUCTION
cell culture-based influenza vaccines production
inoculation of virus
incubation
virus growth
separation, filtration, purification
testing and delivery
IMMUNOTHERAPY
human mAb
no rejection
difficult to generate
mouse hybridoma manipulation
B lymphocytes of peripheral blood
to detect unknown antigens
to discover cellular surface components
vectors to bring drug to the target cell
cancer cells