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42-Compare the general mechanisms that allow some newly synthesized…

- - - - Soluble in ER lumen
        
        signal sequence is cleaved
    - - Single pass
        
        Type I
        
        Signal sequence that gets cleaved
        
        Stop transfer sequence
        
        Single internal start transfer signal
        
        Type III: C-terminus cytosolic
        
        Type II: N terminus cytosolic
      - Multipass
        
        Type IV
        
        Type A: N & C on same side
        
        Type B: N & C on opposite sides
        
        Multiple internal start and stop transfer signals
  - - - Importin
        
        Ran + GTP required
      - not cleaved
      - Nuclear Pore Complex
      - Usually folded by cytosolic chaperons
  - - - Mitochondrial chaperones refold the protein