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41-Explain the mechanism and function of the unfolded protein response and…
41-Explain the mechanism and function of the unfolded protein response and its
value to the cell
Accumulation of misfolded proteins
ER Stress
IRE1
Dimerization
Activation of mRNase
Splicing XBP-1 mRNA
XBP-1 translation
XBP-1 entering nucleus
ER-chaperons genes activated
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ATF-6
Activation & migration to Golgi
Cleavage of cytosolic domain
Migration towards nuclease
PERK
Dimerization & autophosphorylation
Phosphorylation
NFR2
Freeing from inhibitory KEAP1
Migration towards nucleus
elF2A
Inhibition of further protein translation