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Syed Hassan Case Book 1 - Coggle Diagram

- - - - Cellulitis: Blood results, microbiology results are indicative of an infection.
        
        Clarithromycin is prescribed
  - - - Rhabdomylosis. death of the muscle fibres and release of their contents into the bloodstream
        
        sequestration (fluid leads from muscle cells into the extracellular space) --> metabolic acidosis, high anion gap
        
        Metabolic acidosis --> leads to tubular damage (it causes myoglobin to dissociate which has a nephrotoxic effect)
        
        Myoglobin release = kidney casts --> proximal tubular cell damage
        
        Acute Kidney Injury: AKI develops in 10-40% of patients
- - - - Clarithromycin + Simvastatin = Increased risk/ worsening of Rhabdomylosis