Calcium Channel Blockers: Amlodipine

Pharmacokinetics

Pharmacologic Effects

Side Effects

Contraindications

Pharmacologic Effects

Angiotensin-converting enzyme inhibitors (ACEIs): Lisinopril

Side Effects

Contraindications

Pharmacokinetics

64%-90% bioavailable after oral administration.

93% protein binding.

Primarily metabolized in the liver.

Half-life: 30-50 hours.

Decreases myocardial oxygen demand.

Decreases systemic vascular resistance and blood pressure.

Peripheral edema

Headache

Flushing

Dizziness

Palpitation

Nausea

Fatigue

Advanced aortic stenosis

Severe hypotension CHF

Hepatic disease

Lactation

Children under the age of six

Oral administration.

Incompletely absorbed from the GI tract.

25% protein binding.

Removed by hemodialysis.

Half-life: 12 hours. (Prolonged in those with impaired renal function)

Reduces peripheral arterial resistance, B/P, afterload, pulmonary capillary wedge pressure, and pulmonary vascular resistance.

In those with heart failure, also decreases heart size, increases cardiac output, and exercise tolerance.

Headache

Dizziness

Postural hypotension

Chest discomfort

Fatigue

Rash

Abdominal pain

Nausea

Upper respiratory infection

History of angioedema from previous treatment with ACE inhibitors.

Lactation

Renal disease

Hyperkalemia