Calcium Channel Blockers: Amlodipine
Pharmacokinetics
Pharmacologic Effects
Side Effects
Contraindications
Pharmacologic Effects
Angiotensin-converting enzyme inhibitors (ACEIs): Lisinopril
Side Effects
Contraindications
Pharmacokinetics
64%-90% bioavailable after oral administration.
93% protein binding.
Primarily metabolized in the liver.
Half-life: 30-50 hours.
Decreases myocardial oxygen demand.
Decreases systemic vascular resistance and blood pressure.
Peripheral edema
Headache
Flushing
Dizziness
Palpitation
Nausea
Fatigue
Advanced aortic stenosis
Severe hypotension CHF
Hepatic disease
Lactation
Children under the age of six
Oral administration.
Incompletely absorbed from the GI tract.
25% protein binding.
Removed by hemodialysis.
Half-life: 12 hours. (Prolonged in those with impaired renal function)
Reduces peripheral arterial resistance, B/P, afterload, pulmonary capillary wedge pressure, and pulmonary vascular resistance.
In those with heart failure, also decreases heart size, increases cardiac output, and exercise tolerance.
Headache
Dizziness
Postural hypotension
Chest discomfort
Fatigue
Rash
Abdominal pain
Nausea
Upper respiratory infection
History of angioedema from previous treatment with ACE inhibitors.
Lactation
Renal disease
Hyperkalemia