Please enable JavaScript.
Coggle requires JavaScript to display documents.
DNA structures - Coggle Diagram
DNA structures
Holliday Junction
-
-
-
Structure of 2 double-stranded DNA in a X-formation and consists of homoduplex region and heteroduplex region. Heteroduplex region is where 2 strands from different double-stranded DNA are bind together
Depending on the axis that Resolvase cuts, it will determine if a recombinant is formed. A vertical axis cut will form a recombinant due to equal partial amounts of the 2 double-stranded DNA being present, while a horizontal cut will not form a recombinant due to majority of the double-stranded DNA being the same where only a small region is different
Formation of this involves the Invasion of one double-stranded DNA to another double-stranded DNA which is highly homologous, then a D-loop is formed, then cleavage followed by ligation will occur. Finally isomerization will occur to form the Holliday Junction
DNA Hairpin
-
-
-
Possible function of hairpin formation on lesions so that transcription can still occur with only a minor loss of genetic information rather than the loss of all genetic information after the lesion
Structure consists of a stem which is where the complementary bases bind to one another, and there is also the hairpin loop which consists of the bases present between the upstream and downstream complementary bases
G-Quadruplex
-
Forms due to guanine rich sequences and hydrogen bonds being formed between the guanines and metal ion in the center
Function of protecting the genetic information found in the chromosome from external damage such as nucleases (usually found in telomeres)
Structure consists of multiple G-quartets, and each G-quartet is formed by 4 guanines forming hydrogen bonds to a metal ion in the center. The metal ion in the center helps to stabilize the structure and there are hydrophobic interactions/Van der waals interaction between each quartet to stabilize the structure as well.
G-Quadruplex does not follow Watson-Crick pairing, it follows the Hoogsteen pairing
Cruciform
-
-
Function of modifying the DNA to either allow access of proteins to DNA or not allow access of proteins to DNA
-