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COVID-19 - Coggle Diagram
COVID-19
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Pencegahan
Avoid touching face, eyes, nose, and mouth with unwashed hands
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Struktur Virus
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Non structural Protein
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replication gene, ORF1a and ORF1b
Viral Protein
- 13 non-structural proteins of wORF1ab
- three structural proteins (wS, wE, and wN)
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Patofisiologi
Lung cells
increases DAMPs activated macrophages release of chemokines and cytokines, which induce
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Kidney Cell
activates the complement system, which induces
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hypoxia conditions, induced by molecular oxygen exchange
perturbation, increase ROS production, and activate HIF-1
increases macrophages, T cells, and cytokines
Heart Cell
induces inflammation, edema, and necrosis
increases cardiomyocyte hypertrophy via the activation of Ang II,
vasoconstriction, and blood pressure.
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CMD
Anamnesis
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riwayat perjalanan atau tinggal di luar negeri yang melaporkan transmisi lokal dalam 14 hari terakhir sebelum timbul gejala
riwayat perjalanan atau tinggal di area transmisi lokal COVID -19 di Indonesia dalam 14 hari terakhir sebelum timbul gejal
Riwayat kontak dengan pasien konfirmasi atau probabel COVID- 19 dalam 14 hari terakhir sebelum timbul gejala
Pem.fis
Nadi meningkat, RR meningkat
inspeksi dapat tidak simetris statis dan dinamis fremitus mengeras, redup pada daerah konsolidasi suara napas bronkovesikuler atau bronkial, ronki kasar
PP
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Swab Nasofaringeal : Rapid Antigen, PCR
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Replikasi Virus
Attachment, penetration, and uncoating Translation and transcription of viral RNA
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Immunologi virus
Innate response, Via Natural Killer Cell
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Transmisi : Human to human, Droplet