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Q 45:Discuss reversible and irreversible modification of proteins in…
Q 45
:Discuss reversible and irreversible modification of proteins in signaling
transduction pathways
Reversible modification
Phosporylation
Use of Kinases
Addition of Inorganic Phosphate
No need of ATP
Enzymatic control
Transmembrane receptors
GPCR
RTKs
non RTKs
Ser-thr kinases
.
Dephosphotylation
Use of phosphatases
Removal of Inorganic Phosphate
Need of ATP
Threonine, Serine and Tyrosine
Post-translational events
Irreversible modification
Methylation
Addition of methyl group
Acetylation
Addition of acetyl group
Glycosylation
Use of glycolystranspherase
N-linked
in RER
Asparagine
O-linked
in Cis Golgi Apparatus
Threonine or Serine
Ubiquitination
Use of Ubiquitin
Ubiquitin attached to lysines residues
Destruction by a proteosome
Proteolysis
Use of proteases
Breakage of peptide bonds
Notch delta system
.
Conformational changes
Motor proteins
Muscle contraction
ATP use
.
Unidirectional