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imipramine (Tofranil) - Coggle Diagram
imipramine (Tofranil)
Contraindication
Post MI
Narrow Angle Glaucoma
Renal/liver impairment
Use of MaOi within 2 weeks
Adverse Effects
Sedation
Drowsiness
Blurred vision
Dysrhythmias
Uses
Major depression
Bed wetting
anxiety
Drug-Drug Interactions
cimetidine will inhibit metabolism of Tofranil = toxicity
Tofranil will reduce effects of clonidine causing increase in BP/HR
use of Anti-thyroid = lead to agranulocytosis
Administration Alerts
2-3 weeks to gain therapeutic effect
may increase anticholinergic drugs
DON"T D/C suddenly =rebound dysphoria
Herbal Interactions
use of Ginkgo = decreae seizure threshold
St. Johns Wort = Serotonin Syndrome
Mechanism of Action
Blocks the reuptake of NE & serotonin
BLACK BOX WARNING
RISK OF SUICIDAL THOUGHTS (CHILDREN, ADOLESCENTS, YOUNG ADULTS) WITH MAJOR DEPRESSION