Secondary Syphilis: Rough, red, or reddish brown skin rashes that can appear on the palms of the hands and soles of the feet. Mucous membrane lesions of the mouth, vagina, or anus. Other symptoms include fever, swollen lymph glands, sore throat, patchy hair loss, headaches, weight loss, muscle aches, and fatigue. Symptoms will eventually disappear, but without treatment, the infection will go into the latent phase of infection.