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naloxone (Narcan) - Coggle Diagram
naloxone (Narcan)
Adverse Effects
Tremors
Increase BP
Hyperventilation
N & V
Rapid Loss of Analgesia
Administration Alerts
Administer if RR is <10 bpm
may cause opioid withdrawal immediately in physically dependent patients
Keep resuscitative equipment accessible
Treatment Overdose
Oxygen
IV Fluids
Vasopressors
Uses
Reverse of opiate initiated respiratory depression
post operative opioid depression
Mechanism of Action
block/prevent opioid binding to MU, Kappa receptors
Contraindications
Do not use if Resp Depression is due to non-opioid medications
Drug-Drug Interactions
Reversal of analgesic effects due to opioid agonists and mixed agonist drugs
Herbal Interactions
Echinacea can increase risk of hepatotoxicity