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morphine (Astromorph/Duramorph) - Coggle Diagram
morphine (Astromorph/Duramorph)
Mechanism of Action
binds to MU, Kappa receptor
Uses
Severe Acute/Chronic Pain
MI
Pre-Anesthetic
Administration Alerts
Can vasodilate = orthostatic hypotension
Extended release = do NOT crush/chew
PREGNANCY CATEGORY D IS USED LONG TERM
Adverse Effects
Constipation
Overdose = Respiratory depression & Cardiac arrest
Tolerance/ abuse potential
Restlessness, anxiety, depression
BLACK BOX WARNING
EPIDURAL USE: MONITOR FULLY STAGGER 24 HR; DON'T BREAK OPEN/CRUSH; NO ALCOHOL AS IT CAN CAUSE FATAL RESPIRATORY DEPRESSION
Treatment Overdose
IV Naloxone
Activated Charcoal
Contraindications
Severe hepatic/renal impairment
gallbladder disease = increase biliary tract spasms
Acute/Severe Asthma b/c of severe AE respiratory depression
Drug-Drug Interactions/herbal
use of CNS depressants can increase drug effects = respiratory depression
Kava, valerian, St. Johns Wort