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Immuno oncology, macrophages, dendritic cells - Coggle Diagram
Immuno oncology
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immune therapy
antibody
Mab bind to tumor antigen to allow antibody dependent cellular cytotoxicity. can also attach toxin to antibody
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vaccine
tumor antigen exposed to the patient artificially to help build immunity or vaccinate against oncogenic viruses
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innate
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complement
form membrane attack complex through the classical pathway or use spontaneous C3 hydrolysis through alternative pathway
NK cells
recognize PAMP or antibodies on the surface of cancer cells to secrete granzymes(ROS) and perforins(bore holes to increase osmotic pressure)
adaptive
Cytotoxic T cells
activated by dendritic cells and mount immune response
against cells that have the same tumor antigen expressed in their
MHC1
B cells
undergo clonal selection, class switching affinity maturation and clonal expansion to become plasma cells that produce tumor specific antibodies
Helper T cells
TH1 activate macrophages,TH17 allow B cell class switching to produce IgG
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