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Perfusion (Liver), Cognition #, Metabolic Regulation #, Inflammation # -…

- - - - Produce bile salts
        
        Digestion & absorption of fats
      - Eliminate bilirubuin
        
        Conjugate bilirubin
        
        Prevent Jaundice
        
        Causes
        
        Excess RBC destruction
        
        Impaired uptake of bilirubin
        
        Decreased bilirubin conjugation
        
        Bile obstruction
      - Metabolism of steroid hormones
        
        Control aldosterone
        
        Regulate water & sodium
      - Metabolism of drugs
      - Carbohydrate metabolism
        
        Gluconeogenesis
        
        Glycogenolysis
      - Fat metabolism
      - Protein metabolism
        
        Oxidative deamination
        
        Amino acids -> Ammonia
        
        Ammonia + CO2 -> Urea
      - Store minerals & vitamins
      - Filter blood
    - - ALT
      - AST
      - Albumin
      - PTT
      - ALP/ GGT/ ALP
      - Ultasonography
    - - Causes
        
        ETOH
        
        Viral
        
        Any chronic inflammation
      - Liver Cirrhosis
        
        Portal Hypertension
        
        Portal systemic shunt
        
        Renal vasoconstriciton
        
        Low GFR
        
        AKI
        
        Decreased liver blood flow #
        
        Hepatic encephalopathy
        
        Asterixis & DLOC
        
        Decr estrogen metabolism
        
        Decr. bilirubin conjugation
        
        Jaundice
        
        Hypoalbuminemia
        
        Decr clotting factor production
        
        Coagulopathy
        
        HI INR #
        
        Fluid pushes into tissues & peritoneal cavity
        
        Ascities
        
        Hepatosplenomegaly