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celiac disease - Coggle Diagram
celiac disease
complications of celiac disease
lactose intolerance
bone weakness
malnutrition
infertility / miscarriage
nervous system problem
cancer
signs and symptoms of celiac disease
unexpected weight loss
failure to thrive
abdominal distention
chronic diarrhea
infertility
thus the need of further
anatomy of the small intestine
jejunum
ileum
duodenum
descending
second
horizontal
third
superior
first
ascending
fourth
nerve supply of the small intestine
parasympathetic supply
vagal
sympathetic supply
from spinal cord segments T9 - T11
and
histology of the small intestine
mucosa
cell types
paneth cells
Tuft cells / chemosensory cells
transit - amplifying cells
neuroendocrine cells
crypt based columnar cells + stem cells
goblet cells
absorptive cells / enterocytes
membranous epithelial cells
submucosa
loose areolar CT
muscularis externa
2 layers of smooth muscles
inner
circular
outer
longitudinal
serosa or adventitia
adventitia
loose CT
serosa
mesothelial lining
structures determines what functions take place and thus understanding pathologies
differential diagnosis of iron deficiency anemia
blood loss
colon polyps and carcinoma
hookworm infection
peptic ulcer disease
menorrhagia
trauma
decreased supply
nutritional deficiency
malabsorption
gastrectomy
disorders that affect the mucosal cells
H.pylori infection
celiac disease
atrophic gastritis
bariatric surgery
increased demands
pregnancy
growth in children
patients with celiac disease should prevent eating
biochemistry of digestion and absorption
digestion of protein
begins in the stomach
absorption of proteins
active transport
digestion of lipids
begins in small intestine
absorption of lipids
passive transport
digestion of carbohydrates
begins in the mouth
absorption of carbohydrates
active transport
celiac disease resulted from
causes and risk factors of celiac disease
genetic factors
HLA DQ 2/8 predisposition
auto-antibodies
anti-tissue transglutaminase
anti-endomysial
anti-gliadin
triggers and stressors
surgery
pregnancy
viral infection
gluten ingestion
which results in
management of celiac disease
gluten free diet
vitamins and minerals supplements
glucocorticoids
preventing further complications
investigations in celiac disease
antibody blood test
endoscopy
to diagnose and
pathophysiology of celiac disease
gliadin deaminated
binding to APC
immune cell activation
CD4+ T cells
proinflammatory cytokine release
B cell activation
crypt hyperplasia
increase lymphocytes
villous atrophy
mucosal disease
and the patient will have
gluten
group of seed storage proteins found in the endosperm of the seeds of certain cereal grains
protein
gluten = gliadin + glutenin
dominant amino acids are
proline
glutamine
sources
wheat
rye
barley
oat
triticale
malt
brewers yeast
wheat starch
which is a protein
psychosocial factors in celiac disease
certain strategies to cope with celiac disease and prevent flare ups
returning the structure and function back to normal