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Classifications of Liver Pathology - Coggle Diagram
Classifications of Liver Pathology
hepatocellu damage
tests
ALT (SA), SDH (LA), AST
+/- GGT in LA
damage enz are
not func markers
does NOT indicate
specific cause
mild to severe
poor perfusion leading to anemia/hypoxia
toxic (more likely when severe)
mushroom
NSAID
xylatol
mild to mod, can be marked
inflamm/infec (can be marked)
neoplasia
reversibil/prog
FUNC
end stage liver dysfunc can have low lvls from dec hepatic mass
may not have enough hepatocytes left to create enz to inc in serum
dec liver func, liver failure, hepatic insuffic
abil to func
lg func reserve
failure does not occur until 70-80% func reserve is lost
Hard to detect in tests unless very severe
what dec liver func
abnorm
congen
shunts
"liver dysfunc"
acq
toxicity
inflamm/infec
neoplastic
lab results
supportive of dec liver func
DAMAGE TO CHOLESTATIC ENZ LVLS DO NOT PREDICT LIVER FUNC
<30% reserve can lead to alt in
synthetic parameters
what liver makes
dec
alb
choles
glucose
last thing to dec (needed everywhere)
BUN
USG
fibrinogen
not really globulins produced by lymphoid tis
mk inc
PT
bc dec synth + impaired bile flow = dec Vit K dep coag factors (2, 7, 9, 10)
PTT
+/- inc bilirubinemia/uria from func/hepatic hyperbilirubinemia
true tests of liver func
serum bile acids
blood ammonia
liver failure may result from liver dz =
liver fails to clear the blood of things norm elim by liver
liver fails to make substances norm prod by liver
can be secondary to primary dz
IBD
pancreatitis