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Tests for Liver Function - Coggle Diagram
Tests for Liver Function
blood ammonia
produced in intestines by bact diges of aa and urea
carried to liver via portal circu
converted to urea w/in liver for detox
liver has lg reserve capacity
testing
fairly specific for liver dysfunc
req meticulous smpl collection and handling
less sensi than bile acids
inc when
most common: dec liver func or portovascu abnorm
acute/severe GI dz (colic) in horses
ammonia overload in rum
urea cycle enz defic
congen defect (unicorn)
RESULTS ARE NOT ALTERED BY CHOLESTASIS
bilirubin
weak func parameter
varia cause of inc
can be norm in liver dysfunc
dec are
NOT
sig
inc when
prehepatic/hemolytic
mild to very high dep on severity of hemolysis
will not inc bile acids
unless there is liver dz or hypoxia damaging the liver
hepatic/func
scenarios
dec liver func
vascu abnorm
fasting (mild to mod?)
func cholestasis
will inc bile acids
obstructive hepatic or post-hepatic cholestasis
mild to very high dep on severity/chronicity
will inc bile acids
NOT in vitro hemolysis, on in vivo
horses
fasting
12 hrs of fasting = inc bili
2-4 d inc bili 5-8x RI
dogs
low lvls can be norm in urine
cats
bili is never norm in urine
bile acids
inc
abnorm circu
PSS
hypoplasia
if bile acids aren't cleared by liver and enter circ
dec liver func
liver dysfunc from lack of hepatic growth
hepatocytes cannot uptake bile acids from portal blood
spont gall bladder contrac (when SA smell food)
cholestasis (often obstructive)
dec bile acid excre w backwards blood reflux
occurs from
func or sepsis assoc
leakage from bile duct or gb
hepatic or post hepatic
obstruc
hepatocyte swelling
neoplasia
inflamm
very mild post prandial inc is norm
NOT RUN IF BILI IS ALREADY ELEV
bili and bile acids are part of bile = both have excre pthwy, if bili is inc, bile acids are also inc
when to measure
LA
whenever!
SA
pre and post prandial bile acids
2 hrs after being fed high fat content diet
dec
cause from intes malabsorp or dz
don't care bc not common test
synth in hepatocytes from choles
secre into bile after conju
stored in gall bladder (if ani has one)
released into GIT to help diges and absorp f fat/fat solu vits
maj of bile acids resorbed in ileum
enter portal circu
recycled via hepatocytes for use
bile acids should not be in circu in health