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Type IV (delayed or cell mediated) Ch.18 lecture 4 - Coggle Diagram
Type IV (delayed or cell mediated) Ch.18 lecture 4
Graft vs host disease
dr's will use bone marrow allografts to treat leukemia and lymphoma
donates bone marrow T cells foreign
immune response begins resulting in this
Tx
immunosuppressive drugs
tissue typing
used to match donor and recipient
4 classes of immunosuppressive drugs
glucocorticoids
cytotoxic drugs
cyclosporine
lymph- depleting therapies
Glucocorticoids
Steroids
prednisone and methylprednisone common
suppress the response of T cells to antigens and stop mechanism as T cells cytotoxicity and cytoline production
Cytotoxin drugs
Stop mitosis and cytokineses
Cyclophosphamide
Azathioprine
Cyclosporine
prevents making of interluekins and interferons by T cells
blocks Th1 responses
less toxic
combined with glucocorticoids
lymphocyte depleting therapies
reduces adverse side effects associated with immunosuppressive drugs
administering antiserum called anti-lymphocyte globulin
Autoimmune diseases
common features
occurs mostly in elderly
common in men than women
results when person makes antibodies or cytotoxic T cells against normal body cells