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Investigating T cell energy prioritization - Coggle Diagram
Investigating T cell energy prioritization
Aim1: Effector function as major energy sink
Actin cytoskeleton
Components
Integrin-mediated mechanotransduction
Forcing cells into shape: The mechanics of actomyosin contractility
Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks
Actin cytoskeletal dynamics in T lymphocyte activation and migration :check:
Metabolism
actin-atp hydrolysis is a major energy drain for neurons :check:
Crosstalk between mechanotransduction and metabolism
Fueling the cytoskeleton-links between cell metabolism and actin remodeling
Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK
Mechanical regulation of glycolysis via cytoskeleton architecture
Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton
Rapid Glucose Depletion Immobilizes Active Myosin V on Stabilized Actin Cables
Degranulation
Tyrosine kinase activity and remodelling of the actin cytoskeleton are co-temporally required for degranulation by cytotoxic T lymphocytes
Signals controlling lytic granule polarization at the cytotoxic immune synapse
Mechanics
Migration
tumor infiltration
Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model
Migrating into the Tumor: a Roadmap for T Cells
Mechanism
PIP3 Waves and PTEN Dynamics in the Emergence of Cell Polarity
Vimentin Intermediate Filaments Template Microtubule Networks to Enhance Persistence in Cell Polarity and Directed Migration
The interface between biochemical signaling and cell mechanics shapes T lymphocyte migration and activation
T Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors :check:
Spatiotemporal Feedback between Actomyosin and Focal-Adhesion Systems Optimizes Rapid Cell Migration
Protein kinase C: a regulator of cytoskeleton remodelling and T-cell migration :check:
Myosin-IIA and ICAM-1 Regulate the Interchange between Two Distinct Modes of T Cell Migration1 :check:
Mechanical modes of ‘amoeboid’ cell migration :check:
Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration
Effect of inhibitors of Na+/H+-exchange and gastric H+/K+ ATPase on cell volume, intracellular pH and migration of human polymorphonuclear leucocytes
Metabolism
Metabolic Control of Innate Lymphoid Cell Migration :green_cross:
Metabolism, migration and memory in cytotoxic T cells :check:
Implications of cellular metabolism for immune cell migration :check:
Bioenergetics underlying single-cell migration on aligned nanofiber scaffolds
Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration
AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion
2D
3D
Water Permeation Drives Tumor Cell Migration in Confined Microenvironments
The spatiotemporal control of effector T cell migration
Rapid leukocyte migration by integrin-independent flowing and squeezing
On the energy efficiency of cell migration in diverse physical environments
Migration of Cytotoxic T Lymphocytes in 3D Collagen Matrices
Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration
Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making
Cellular locomotion using environmental topography
A cellular sense of space and pressure
IS
Structure
Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions
Actin clearance promotes polarized dynein accumulation at the immunological synapse
CTL activation
Metabolism
T lymphocyte aggregation with immobilized anti-TCR-antibodies is dependent upon energy and microfilament assembly
Metabolic coordination of T cell quiescence and activation
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
T Cell Activation Depends on Extracellular Alanine :check:
Regulation of cytotoxic T-lymphocyte activation by l-lactate and pyruvate
T Cell Activation: The importance of methionine metabolism
Mechanism
Cytotoxic immunological synapses :check:
Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL
Functional Anatomy of T Cell Activation and Synapse Formation :check:
Regulation of cytoskeletal dynamics at the immune synapse: New stars join the actin troupe
Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm
T-cell-receptor-dependent actin regulatory mechanisms
The calcium feedback loop and T cell activation: How cytoskeleton networks control intracellular calcium flux
The cytotoxic T lymphocyte immune synapse at a glance
The kinetic-segregation model: TCR triggering and beyond
Modulating T cell activation using depth sensing topographic cues
T cell antigen receptor activation and actin cytoskeleton remodeling
Mechanically active integrins direct cytotoxic secretion at the immune synapse
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity
Mechanical forces in the immune system
Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells
The interface between biochemical signaling and cell mechanics shapes T lymphocyte migration and activation
Myosin II activity
T cell receptor signaling and immunological synapse stability require myosin IIA
Aim2: Housekeeping as major energy sink
Translation
Protein synthesis, degradation, and energy metabolism in T cell immunity :check:
Translation in amino-acid-poor environments is limited by tRNAGln charging
Translational control in stress and apoptosis
Nutrient Deprivation Elicits a Transcriptional and Translational Inflammatory Response Coupled to Decreased Protein Synthesis
Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin :check:
Dynamics in protein translation sustaining T cell preparedness :check:
Translation is actively regulated during effector CD8+ T cell differentiation
Stress-Mediated Attenuation of Translation Undermines T Cell Tumor Control
Transcription
Nutrient Deprivation Elicits a Transcriptional and Translational Inflammatory Response Coupled to Decreased Protein Synthesis
Connecting Variability in Global Transcription Rate to Mitochondrial Variability
Nutrient regulation of signaling and transcription
Molecular mechanisms driving transcriptional stress responses
Ca2+ signaling
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI
Na+/K+ ATPase
Aim3: Exhausted T cell
Migration
Active surveillance characterizes human intratumoral T cell exhaustion :check:
Tireless surveillance by exhausted T cells
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis :check:
IS
MDJ data
Housekeeping
Definition
Epigenetics
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
Chromatin states define tumour-specific T cell dysfunction and reprogramming
Metabolic and epigenetic regulation of T-cell exhaustion
T Cell Dysfunction in Cancer
T cell exhaustion
Tolerance and Exhaustion: Defining Mechanisms of T cell Dysfunction :check:
TOX is a critical regulator of tumour-specific T cell differentiation
What do we mean by T cell exhaustion and/or dysfunction and how would you define this state?
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
Metabolism
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen
Metabolic and epigenetic regulation of T-cell exhaustion
Cause of exhaustion
Bioenergetic insufficiencies due to metabolic alterations regulated by PD-1 are an early driver of CD8+ T cell exhaustion
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion
Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis
T cell stemness and dysfunction in tumors are triggered by a common mechanism
Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment
Immune checkpoint
Immune Checkpoint Receptors Signaling in T Cells
AMPK
mechanical activity
AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion :check:
Assembly of Peripheral Actomyosin Bundles in Epithelial Cells Is Dependent on the CaMKK2/AMPK Pathway :check:
AMPK negatively regulates tensin-dependent integrin activity
AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells :check:
AMP-activated Protein Kinase Impairs Endothelial Actin Cytoskeleton Assembly by Phosphorylating Vasodilator-stimulated Phosphoprotein
Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK
AMP-activated protein kinase: balancing the scales
T cell
The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo :check:
The role of AMPK in T cell metabolism and function
Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes :check:
Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen species
Deficiency of AMPK in CD8 + T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death
Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry
AMPK: restoring metabolic homeostasis over space and time :check:
AMPK directly activates mTORC2 to promote cell survival during acute energetic stress
Autophagy regulation by nutrient signaling
Other readings
TME
Competition for nutrients and its role in controlling immune responses
Metabolic landscape of the tumor microenvironment at single cell resolution
Microenvironmental influences on T cell immunity in cancer and inflammation
Nutrients and the microenvironment to feed a T cell army
T cell exclusion, immune privilege, and the tumor microenvironment
Nutritional Exchanges Within Tumor Microenvironment: Impact for Cancer Aggressiveness :check:
Cell-programmed nutrient partitioning in the tumour microenvironment. :check:
Metabolism
A guide to immunometabolism for immunologists :check:
Cellular energy utilization and molecular origin of standard metabolic rate in mammals :check:
A hierarchy of ATP-consuming processes in mammalian cells. :check:
Control strategies in systemic metabolism
Nutrient Sensing Mechanisms and Pathways
Nutrient Sensing, Metabolism, and Cell Growth Control
Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake
The activation of Akt/PKB signaling pathway and cell survival
T cell specific metabolism
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability :check:
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
Lipid Signaling in T-Cell Development and Function
Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
Metabolic Control of CD8+ T Cell Fate Decisions and Antitumor Immunity
Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells :check:
Metabolic Regulation of T Lymphocytes
Targeting Pim2 for Improving T-Cell Effector Function and Promoting Cancer Immunotherapy
Fuel feeds function: energy metabolism and the T-cell response
Metabolic reprograming of anti-tumor immunity
Nutrient and Metabolic Sensing in T Cell Responses :check:
T cell metabolism drives immunity
The Pim Kinase Pathway Contributes to Survival Signaling in Primed CD8+ T Cells upon CD27 Costimulation
The Pim kinases control rapamycin-resistant T cell survival and activation
The Role of Non-essential Amino Acids in T Cell Function and Anti-tumour Immunity
The role of Pim kinase in immunomodulation
Mitochondrial translation is required for sustained killing by cytotoxic T cells
Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells
Cell death
Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis
T cell
A brief history of CD8 T cells :check: