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UNIT 18 : IMMUNOLOGY - Coggle Diagram

- - - - Pluripotent Hematopoietic stem cell
        
        Myeloid progenitor cell
        
        Red blood cells
        
        Platelets
        
        WBC's
        
        Granular cells
        
        Macrophages : Engulfs and digests microorganisms + activates T-cells
        
        Monocytes: Mature into macrophages
        
        Mast cells : Releases histamine when damaged
        
        Neutrophils: Phagocytose pathogens
        
        Eosophils: Kill antibody coated parasites
        
        Dedritic cells : Present antigen to the T-cells
        
        Basophils:Release histamine and promotes the development of T-cells
        
        Lymphoid progenitor cell:
        
        T-cells : Attack virus-infected cells & control the activities of other white blood cells
        
        Natural killes : Attack and lyse virus-infected or cancerous cells
        
        B-cells : Differentiate into antibody-producing or memory cells/ They produce a specific class of antibodies at a time but they can do what's called as class switching and produce a new se of antibodies. Early B cells produce IgM
  - - - -Proteasome break the protein into small peptides/ peptides will get carried to the E.R where one of them will permanently bind to the MHC. The protein loaded complex is pinched off in a vesicle which will fuse with the plasma membrane
      - The cellular response result in the production of cytotoxic cells that will cause cell to undergo apoptosis
    - - In the endosome peptide fragements, interact with the MHC-II
      - It results in the prodcution of immunoglobins which are antibodies
  - - - The complementary system is made of antimicrobial proteins , it's found in vertebrate blood
        
        Inflammation is a response to an injury. Mast cells bind to the are and release histamine (basophils also release histamines) which will cause the dilation of blood vessesl. The are shows redness. If the inflammation spreads this is called as sepsis