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Actin cytoskeleton - Coggle Diagram
Actin cytoskeleton
Components
WASP
barbed ends
Capping proteins
pointed ends
Profilin
cofilin
thymosin-b4
Fascin
Arp2/3 complex
WAVE
PP1 & 2A
L-plastin
LIM kinase 1&2
wip
Ena/ VASP
polyphosphoinositides
Immune synapse
structure
Central SMAC
TCR, PKCtheta, Lck
Peripheral SMAC
LFA-1
distal SMAC
CD45 rich
TCR signaling
Activation
ZAP70
SLP76
LAT
Actin polymerization
Vav1
Rac1
cdc42
Anchor/ adaptor protein
paxillin
Fyb/SLAP
vinculin
Migration
Structure
filopodia
DOCK8 --> cdc42
MTOC
lamellipodia
Rac1
uropod
RhoA; contraction
ERM proteins
Signaling
PIP2, PIP3
Metabolism