Please enable JavaScript.
Coggle requires JavaScript to display documents.
Psychosis - Coggle Diagram
Psychosis
Brief Psychiatric Rating Scale (BPRS)
Age: 18+
Assesses?
psychopathology
With schizophrenia
negative symptoms
affective symptoms
positive symptoms
Not for screening or diagnosis
Pathophysiology
Pathways
mesocortical
executive function
attention
focus
depression
nigrostriatal
from substantia nigra (brainstem) to striatum (muscles)
Parkinson's
mesolimibic
projects to nucleus accumbens (limbic system)
pleasure
reward
positive symptoms of psychophrenia
addiction
gambling
neurotransmitters
Elevated
Dopamine
tuberoinfundibular
regulation of prolactin (acts on pituitary)
hypersexuality in mania
Neuro transmitters
Dopamine
Produced in
substania nigra
Ventral tegmental Area
Receptors
D2 (most common)
D4
Elevated in psychosis
Serotonin
5HT
Produced in?
Raphe Nuclei
Effects
emtion
impulses
dreams
5HT2A receptors = atypical antipsychotics
Positive & negative symptoms
scales
Positive & Negative Syndrome Scale (PANSS)
Age: 18+
Assesses
changes in symptom intensity in psychosis & schizophrenia
Gold standard in studies of treatment efficacy
Medications
Antipsychotics
MOA:
Block dopamine in
tuberinfundibular
nigrostriatal
mesolimibic
mesocortical
FGA vs SGA
first generation
dopamine (D2) receptors
Second generation
Dopamine
5HT2A receptors