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Mania - Coggle Diagram
Mania
Medication
Valproex Acid
Labs
CK
Baseline & monthly
Lithium
Labs
creatinine
BUN
electrolytes
cbc w/diff
WBC
Urinalysis
EKG
CK levels
When?
12 hours post dose
after 4 days on med
then q 4-5 days during initial therapy
range
0.6/8 - 1.2 (Varies)
maintenance: 0.6 - 1.0
Lithium toxicity
signs/symptoms
nystagmus
ataxia
increased deep tendon reflexes
altered mental status
cardiac arrhythmias
What meds do to lithium
Increases lithium
ACE Inhibitors (-prils)
ARBs (-sartans)
NSAIDs
tetracyclines
metronidazole
Decreases Lithium
potassium sparing diuretics
sodium channel blockers
aldosterone
spironolactone
thiazide diuretics
theophyine
Gold standard for mania treatment
Depakote
Labs
GFR
normal: 90
best measurement of kidney function
dosing
no need to adjust dose if GFR is 60+
Scales
Mood Disorder Questionnare (MDQ)
Positive = 7+ of 13 items in question #1 AND 2 = yes
Young Mania Rating Scale (YMRS)
11 items (adult)
Scoring
Range: 0-60
12+ = mania