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Antiviral Drugs - Coggle Diagram
Antiviral Drugs
Influenza Virus
Properties
Enveloped capsids of 80-120 nm
Segmented ssRNA genome
There are eight segments of differing lengths
Two surface glycoproteins (HA and NA) which are essential for cell engry and antigenicity
Epidemiology
Influenza A causes more human illness, and is less stable
Antigenic shift
Process of mixing genomic RNA segments when two different subtypes infect the same cell
Influenza B is more stable over time
Treatment and Prevention
Vaccines
Killed inactivated vaccine via injectin
FluMist - live attenuated vaccine (intranasal)
Antivirals
Effective if given within 48 hours of first appearance of symptoms
Oseltamivir
(Tamiflu)
Neurominidase inhibitor
Zanamivir
(Relenza)
neurominidase inhibitor
Herpesviruses
Types
Alpha - latent in sensory ganglia
Herpes Simplex I - Orofacial lesions
Herpes Simplex II - Genital lesions
Varicella Zoster - chicken pox