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Lymphocytes - Coggle Diagram
Lymphocytes
B cells
B Cell Activation
Antibodies
Structure
Light Chains
Consists of
Constant Region
Variable Region
Genes
Igκ gene
Igλ gene
Heavy Chains
Consists of
Variable Region
Constant Region
Genes
IgH gene
Classes
IgM
IgE
IgA
IgD
IgG
B Cell Development
Phase IV
Mature, Naïve B Cells
Circulation
Phase V
Antigen binding leads to
Active B Cells
After activation
Class Switching
Somatic Hypervariability
AID protein
Phase II
Immature B Cell
Negative Selection
Self-antigens
RAG proteins
Anergy
Leaves bone marrow
Bone Marrow
Phase I
Bone Marrow
Pro-B cell
V(D)J recombination
Surrogate light chain
Apoptosis
Pre-B cell
V(D)J recombination
Light chain
Immature B cell
Apoptosis
Phase III
Positive Selection
Immature to Mature, Naïve B Cells
Occurs in
Lymph nodes
Phase VI
B Cell Differentiation
Mature into
Plasma Cells
T Cells
T Cell Recptor
Recognizes
Peptide Antigen
Structure
Consists of
Constant Region
Variable Region
TCR genes
V(D)J recombination
Requires
RAG proteins
Occurs in
Thymus
T Cell Development
In Thymus
Stage 3
Stage 2
Positive Selection
Stage 4
Stage 1
Double-positive Thymocyte
Expresses
CD4
CD8
pre-T-cell receptor