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LUTs drug : storage - Coggle Diagram

- - - - Decrease urgency
      - Increase bladder capacity
  - - - Lipophilic
      - Lower or neuutral charge
      - Well absorb from GI
      - Pass to CNS**
    - - Not well absorb from GI
      - Lower pass to CNS**
      - Drug include
        
        Propantheline
        
        Trospium
  - - - QT prolong
      - polymorphic VT ( Torsades de pointes)
      - Tachycardia
    - - cognitive impairment
      - memory impariment
      - dizziness
      - fatique
      - headache
- - - - Pharmaco
        
        Rapid absorbed
        
        Highly lipophilic
        
        Liver metabolized
        
        CYP450
        
        Drug interaction : ketoconazole
      - Efficacy
        
        No effect on Flow rate, PdetQmax, BCI
        
        No differ with anti-M, but less SE (dry mouth, constipation)
      - SE
        
        GI disorders
        
        Constipation
        
        Dyspepsia
        
        Dry mouth
        
        N/V
        
        Tachycardia
        
        HT
        
        Headache
      - No effect on cardiovascular *
- - - - 5 hydroxymethyl
- - - - A1a * prostate
      - A1b
      - A1d
  - - - A1a-ARs
        
        Effect on nocturia over placebo
        
        SE : retrograde ejaculation > reversible
        
        Voiding + storage
      - Ineffective in OAB tx
- - - - N-desethyloxybutynin (DEO)
      - Dry mouth *
    - - Anti M
        
        Higher affinity M1, M3
      - Muscle relaxant
      - Local anesthetic action