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FACTORS AFFEECTING DISTRIBUTION OF DRUGS - Coggle Diagram
FACTORS AFFEECTING DISTRIBUTION OF DRUGS
Organ/ tissue size and perfusion rate
Tissue permeability of drug
Physiological barriers
Capillaries endothial cells
Blood brain barriers
Blood- CSF barrier
Blood plancental barrier
Blood testis barrier
Physicochemical properties
Molecular size
pKa
o/w partition coefficient
sterochemical
Binding of drug to tissue components
Binding of drug to blood component
Binding of drugs to extravascular tissue proteins
Miscellaneous factors
Age
Pregancy
Obesity
Diet
Disease state
Drug interaction