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Glutamate / GABA Receptors - Coggle Diagram
Glutamate / GABA Receptors
Glutamate Receptors
Ionotropic Receptors
Subtypes
AMPA
Na+ / K+
4 subunits
Fast synaptic potentials
NMDA
Na+ / K+ / Ca2+
Need for co-agonist - Glycine / D-serine
4 subunits
Voltage dependant - Mg2+ blocks channel at Vm
Slow synaptic potentials
Kainate
Presynaptic
Fast transmission
Receptor Type
Ion channel
Metabotropic Receptors
Slow transmission
Subtypes
mGlu1-8
Receptor Type
GPCR
Location
Dendrites
Drugs
Perampanel
AMPA antagonist
Ketamine
NMDA antagonist
GABA Receptors
Subtypes
GABA-A
Pentamer
Cl-
Inotropic
Inhibitory - IPSP
GABA-B
Metabotropic
GPCR: Gi
Slow inhibition
Activate K+ / Inhibit Ca2+
Presynaptic
Drugs
Baclofen
GABA-b agonist
Benzodiazepine
Antagonist
