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Tuberculosis - Coggle Diagram
Tuberculosis
Pathogenesis
Encounter
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Inhaled directly into alveoli without upper respiratory tract colonization (not aspiration pneumonia)
Without intervention, ~10% will develop active disease during life
Spread
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Can seed about any tissue, though lungs are most common
Defense Evasion
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Usually limited by cell mediated immune response, but that only holds it in check, not gone
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Clinical
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Risk factors
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Higher risk
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Certain medical conditions (diabetes, renal failure, certain cancers)
Physical exam is basically not notable which makes it harder. History becomes more important, relatively
Symptoms
Cough, fever, night sweats, appetite loss, weight loss, easy fatigability
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This is a game of our own immune system destroying our tissues. Whoa. That's crazy stuff. Inflammation is a big issue
Patients with, or suspected of having, active TB should be isolated in a negative pressure room if they require admission
Directly observed therapy is the standard of care to treat active TB - Need to watch every single dose!
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