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FPV @ FeLV, Immunosuppression and stresss condition due to OHE and…
FPV @ FeLV
Ingestion/inhalation route
Deposited on mucosal layer of oral pharynx and nasal
Infect and replicate macrophage and dendritic cells
Travel to tonsil and replicate
Spread via leukocyte trafficking in lymphatic and blood vessel (1st viremia)
Mucosa associated lymphoid nodules - Peyer’s patches in the small intestine
Lysis of Peyer’s patches
Hyperplasia of crypt epithelium
Necrotization & sloughing off of epithelial cell
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Bone marrow, LN, spleen
(2nd viremia)
GIT
Long term
Persistent infection
Prolonged antigenemia
Prolonged production of FeLV antibody
Over formation of FeLV antibody antigen binding immunocomplex
Deposition on immunocomplex at gromerulus
immunocomplex glomerulitis
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Type 1 Allergic
Hypersensitivity
Continous irritation to skin
Wound lesion formed difficult to heal
Eosinophilic granuloma complex
shown by histopathologic result present of mast cell and eosinophil
Immunosuppression and stresss condition
due to OHE and diaphragmatic hernia condition