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REPRODUCTIVE HEALTH, AGING, DIABETES, STRESS, DECREASED EMOTIONAL…
REPRODUCTIVE HEALTH
AGING
MENOPAUSE
SEXUAL PAIN
DECREASED LUBRICATION
DECREASED LIBIDO
SEXUAL DYSFUNCTION
FASTING IMPROVES SEXUAL DRIVE
HEALTHY BODY WEIGHT
DECREASE IN ESTROGEN
DECREASE IN PROGESTERONE
ATROPHY AND INFLAMMATION OF VUVLOVAGINAL TISSUE
DECREASE IN TESTOSTERONE
WOMEN INFERTILITY
PCOS
ALCOHOL CONSUMPTION
sexual potency decline
orgasmic frequency decline
sexual thoughts decline
DECREASE IN TESTOSTERONE LEVELS
MEN INFERTILITY
increase in SHBG
DIABETES
Hyperglycemia can dehydrate mucus
membranes, resulting in vaginal dryness and dyspareunia
DECREASED LUBRICATION
vascular and nerve damage of the female genitalia
impaired response to stimuli.
STRESS
ORGASM DISORDERS
DECREASED EMOTIONAL CONNECTION TO A PARTNER
OBESITY
DEPRESSION
HIGH GLUCOSE LEVELS
ARTHEROSCLEROSIS AND DECREASED BLOOD FLOW
vaginal and clitoral vascular insufficiency syndrome
rs2002555 G/G LINKED TO ONSET OF MENOPAUSE
rs11170547 T ALLELE IS LINKED TO ONSET OF MENOPAUSE
rs6521896 IS LINKED TO ONSET OF MENOPAUSE
MITOCHONDRIAL DYSFUNCTION
...
SMOKING
OBESITY
hypertension
ERECTILE DYSFUNCTION
HISTORY OF GYNECOLOGICAL DISRORDERS
ovulatory disorders
endometriosis
pelvic adhesions
tubal blockage and other tubal abnormailites
hyperprolactinemia
disorders of sperm transport such as retrograde ejaculation or anejaculation
endocrine disorders (hypogonadism)
low testosterone levels
Y chromosome microdeletions, monogenic
disorders, and cytogenetic disorders
dyslipidemia
diabetes
Anejaculation
MINDFULNESS MEDITATION TRAINING
ACUPUNCTURE
eNOS activity reduction
nitric oxide which maintains the tumescence phase of erection is reduced due to NOS3 polymorphisms
L-arginine
NO
increase in TMAO levels
vascular inflammation
endocrine disruptors
bad semen quality
poor diet
stress
obesity
irritable bowel syndrome
low antioxidant capacity
lower activity of superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX)
REACTIVR OXYGEN SPECIES
lipid peroxidation (LPO) within the cellular membrane, deoxyribonucleic acid (DNA) fragmentation in nuclei and mitochondria, and apoptosis
reduced semen quality
mobile phone radiation
SMOKING
OBESITY
impaired spermatogenesis due to endocrinological abnormalities
ALCOHOL
POLLUTION
HIGH TEMPERATRUE due to tight‐fitting underwear, using a sauna, bathing for long periods of time, using a laptop on closed legs, and cycling
progesterone levels drop, immediately prior to menstruation
increased prostaglandin levels: PGF2a and PGF2
uterine contractions
blood flow restriction
production of anaerobic metabolites that stimulate pain receptors
MENSTRUAL PAIN or primary dysmenorrhea
anxiety
menstrual pain is associated with depression and anxiety and poor sleep quality
coffee
sugar intake
myometric
muscle contractions
increased synaptic transmission
magnessium deficiency
ANTIOXIDANTS: vitamin E, vitamin C, and β-carotenoids
muscle nervous activities control
CALCIUM INTAKE
smoking
alcohol intake
obesity
stress
depression
PHYSICAL
ACTIVITY
YOGA
OBESITY
sex hormone secretion, oocyte differentiation and maturation, and endometrial implantation, and other reproductive functions are disrupted
DYSBIOSIS
alcohol
MENSTRUAL CYCLE RELATED PROBLEMS
OLIGOMENORRHEA (inconsistent and irregular)
PMS AND PMDD
PSYCHOLOGICAL DISTRESS
stress
HEAVY PERIODS
iron deficiency
AMENORRHEA (absence)
FRUIT AND VEGETABLES
sweets consumption
systemic inflammation - elevated hs-CRP levels
SEROTONIN DYSREGULATION
altered sensitivity to progesterone
altered concentrations of neuroamines,
such as serotonin, dopamine, and norepinepherine
obesity
smoking
menopause
extreme changes in body weight
excessive exercise
stress
stress
menopause
ACE converts angiotensin I into angiotensin II
angiotensin II can cause follicular atresia
ANOVULATION
WOMEN
DIABETES AS RISK FACTOR!!
CVD AS RISK FACTOR!!
DEPRESSION AS RISK FACTOR!!
CALORIC RESTRICTION AS PROTECTIVE FACTOR!!
MEN
POOR WEIGHT MANAGEMENT AS RISK FACTOR
SNPs TO DETECT INCREASED RISKS
LIFESTYLE HACKS
SNPs TO DETECT INCREASED RISKS
DIABETES AS RISK FACTOR!!
CVD AS RISK FACTOR!!
SNPs TO DETECT INCREASED RISKS
LIFESTYLE HACKS
SAUNA CAN UPREGULATE eNOS ACTIVITY AND THUS INCREASE NO LEVELS
eNOS
INCREASED L-ARGININE INTAKE
LIFESTYLE HACKS
FOOD AND SUPLEMENTS
POOR WEIGHT MANAGEMENT AS RISK FACTOR
LIFESTYLE HACKS
yoga, meditation, physical activity
POOR INTESTINAL HEALTH AS RISK FACTOR!!
SUPPLEMENTATION OF ANTIOXIDANTS: ascorbic acid (vitamin C) and alpha‐tocopherol (vitamin E), coenzyme Q10, astaxanthin, myo‐inositol, urate, taurine, melatonin, transferrin, L‐carnitine, and lactoferrin
POOR WEIGHT MANAGEMENT AS RISK FACTOR
INCONSISTENCY!!
POOR WEIGHT MANAGEMENT AS RISK FACTOR
MOOD AS RISK FACTOR
LIFESTYLE HACKS
POOR WEIGHT MANAGEMENT AS RISK FACTOR
DIEATARY INTERVENTIONS
MAGNESIUM
DIEATARY INTERVENTIONS
YOGA AND MEDITATION TECHNIQUE
YOGA AND MEDITATION TECHNIQUE