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DRUG INTERACTIONS - Coggle Diagram
DRUG INTERACTIONS
PK
Distribution
hypoalbuminemia - high toxicity
high protein bound
aspirin
barbiturate
warfarin
phenytoin
Metabolism
Enzyme induction - high metabolism
Cyclosporine vs rifampin
Phenytoin vs erythromycin
Enzyme inhibition - low metabolism
Ketoconazole vs cyclosporine
Cimetidine vs warfarin
Omeprazole vs clopidogrel
Absorption
aspirin + antacid (base)
low gastric pH, low absorption
tetracyclin + Al, Mg, Fe etc
form insoluble complex
Excretion
change urine pH
methotrexate + alkaliniser - high clearance
Enterohepatic recirculation
OCP + penicilin - gut flora killed - OCP not metabolised
change active renal tubular excretion
penicilin + probenecid - inhibit penicilin tubular secretion
PD
Additive
beta agonist bronchodilator + K depleting drugs - hypokalemia
Antipsychotic + Antimuscarinic - high antimuscarinic
Antagonistic
warfarin + vit K - opposed anticoagulant
Drug-Herb
St John wort
(Hypericum perforatum)
CYP3A4 inducer
high metabolism
low drug lvl
cyclosporin
digoxin
Serotonergic effect
interact with SSRI