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PATIENT'S FACTORS - Coggle Diagram

- - - - digoxin
      - lithium
      - penincilin
    - - NSAIDs
      - nephrotoxic antibiotics
    - - thiazide
- - - - olanzapine, theophyline
        
        high metabolism, high clearance
  - - - Interferes normal metabolism/excretion
    - - enhance med's effects (CNS)
- - - - normal
        
        adipose 20%, lean 80%
      - obese
        
        adipose 40%, lean 60%
    - - if use total - drug toxicity
      - use lean body weight
    - - lipophilic distribute - adipose tissue
        
        low plasma conc. , high Vd
        
        Vd - total body weight
        
        phenytoin, midazolam, voriconazol