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Activity 2 - Coggle Diagram
Activity 2
Detoxification
- Hepatocytes are the most active cell in the liver that remove toxins from plasma and eliminate them
- They modify toxin to make it less destructive and add chemical components to make them souble
- These soluble toxins can then be transferred back to the blood and eliminated by kidneys as urine
- Alcohol ---> Less toxic substance by ethanol dehydrogenase
- Toxic ammonia --> urea
- Drugs --> being detoxified as they are biochemicals that are foreign to the body's biochemistry
Jaundice
Cause
Liver disease: Impaired removal of bilirubin by the liver may result in elevated levels in the body.
Obstruction of the gall bladder or bile duct: This prevents bile secretion, causing bilirubin levels to rise.
Red blood cell damage: Increased destruction of erythrocytes, causing bilirubin levels to rise.
Consequence
- Because of the accumulation of bilirubin in blood plasma and skin tissues therefore skin colour and white of the eyes will become yellowish.
- Itchiness and dark urine
- Brain damage can be cause because of the bilirubin levels in blood plasma remained elevated for a long period
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Formation of bile
- Produced by hepatocytes and is modified by cholangiocytes lining the bile ducts
- Surplus cholesterol are being convered into bile salts by hepatocytes
- added to bilirubin to make bile
- Bile secreted into small intestine and the bile salts emulsify the lipids
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