Oronasal exposure to feces contaminated with Canine Parvovirus

Virus replication in lymphoid tissue of the oropharynx, mesenteric lymph nodes and thymus

In utero

Myocardium

Myocarditis

Less than 6 weeks old

Cardiac arrhythmias

More than 3 months old

Chronic myocardial fibrosis

Cardiomyopathy

Congestive heart failure

Pulmonary edema

Death

Neonate (less than 8 weeks old)

Less than 2 weeks old

Generalized

Acute death, 10 days of age

Sudden death

Postnatal (more than 8 weeks old) exposure

Regional lymph nodes, pharynx, tonsils

Marked plasma viremia (1-5 days post-infection)

Minimal pathology

Lungs

Liver

Kidney

Lymphoid tissue

Immunodeficiency, thymic atrophy, generalized lymphoid depletion and lymphopenia

Infects the germinal epithelium of the intestinal crypts of the small intestines

Destruction and collapse of the epithelium

Impair normal cell turnover

Shortened villi

Increased permeability, decreased absorption

Diarrhea

Yellow-gray and are streaked or darkened by blood

Thymus

Lymph nodes

Bone marrow

Gastrointestinal epithelium

Tongue

Oral mucosa

Esophagus

Spleen

Myocardium

Mild

Recovery

Severe

Destroys mitotically active precursors of circulating leukocytes and lymphoid cells

Neutropenia

Lymphopenia

Secondary infection from gram-negative and anaerobic microflora

Intestinal damage

Bacteremia

Endotoxemia

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Enteritis

Vomiting

Anorexia

Dehydration

Disseminated Intravascular Coagulation

Elevated rectal temperature

Lymphopenia

Hemorrhage into the Central Nervous System (CNS)

Hypoglycemia

Acid-base electrolyte imbalance

Mild to moderate lymphohistiocytic meningitis or leukoencephalitis

Cerebral white matter vacuolation

Death

Skin

Ulceration of the footpads, pressure points and vaginal mucosa

Ulceration

Vesicles

Erythematous patches on the abdomen and perivulvar skin

Dyspnea

Crying

Retching

Diarrhea

Apparent recovery

Hypercoagulopathy

Catheters or visceral thrombi

Thrombosis or phlebitis

Fecal contamination of external genitalia

Bacteriuria

Intravenous catheter infection from GI or environmental origin