Oronasal exposure to feces contaminated with Canine Parvovirus
Virus replication in lymphoid tissue of the oropharynx, mesenteric lymph nodes and thymus
In utero
Myocardium
Myocarditis
Less than 6 weeks old
Cardiac arrhythmias
More than 3 months old
Chronic myocardial fibrosis
Cardiomyopathy
Congestive heart failure
Pulmonary edema
Death
Neonate (less than 8 weeks old)
Less than 2 weeks old
Generalized
Acute death, 10 days of age
Sudden death
Postnatal (more than 8 weeks old) exposure
Regional lymph nodes, pharynx, tonsils
Marked plasma viremia (1-5 days post-infection)
Minimal pathology
Lungs
Liver
Kidney
Lymphoid tissue
Immunodeficiency, thymic atrophy, generalized lymphoid depletion and lymphopenia
Infects the germinal epithelium of the intestinal crypts of the small intestines
Destruction and collapse of the epithelium
Impair normal cell turnover
Shortened villi
Increased permeability, decreased absorption
Diarrhea
Yellow-gray and are streaked or darkened by blood
Thymus
Lymph nodes
Bone marrow
Gastrointestinal epithelium
Tongue
Oral mucosa
Esophagus
Spleen
Myocardium
Mild
Recovery
Severe
Destroys mitotically active precursors of circulating leukocytes and lymphoid cells
Neutropenia
Lymphopenia
Secondary infection from gram-negative and anaerobic microflora
Intestinal damage
Bacteremia
Endotoxemia
click to edit
Enteritis
Vomiting
Anorexia
Dehydration
Disseminated Intravascular Coagulation
Elevated rectal temperature
Lymphopenia
Hemorrhage into the Central Nervous System (CNS)
Hypoglycemia
Acid-base electrolyte imbalance
Mild to moderate lymphohistiocytic meningitis or leukoencephalitis
Cerebral white matter vacuolation
Death
Skin
Ulceration of the footpads, pressure points and vaginal mucosa
Ulceration
Vesicles
Erythematous patches on the abdomen and perivulvar skin
Dyspnea
Crying
Retching
Diarrhea
Apparent recovery
Hypercoagulopathy
Catheters or visceral thrombi
Thrombosis or phlebitis
Fecal contamination of external genitalia
Bacteriuria
Intravenous catheter infection from GI or environmental origin