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CANINE DISTEMPER, Cause - Coggle Diagram
CANINE DISTEMPER
Spread by aerosol or droplet exposure
In contact with
epithelium of URT
Multiply in
alveolar macrophage
Spread to local lymphatics to tonsil and bronchial LN via SLAM.
Viral number increased in tonsil, retropharyngeal LN and bronchial LN. Low viral load in lymphoid organs
Virus multiplication in lymphoid follicles of spleen, GALT of lamina propria of stomach and small intestine, mesenteric LN and Kupffer cells.
Viremia
Surface epithelium
Footpad hyperkeratosis & parakeratosis
CNS
Localized involuntary muscle twitching
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Shedding of virus at time of epithelial colonization
Good immune response
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Poor immune rsponse
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Route of shedding
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Leukopenia: Lymphopenia
Destruction of T cells, B cells
Fever
Cause