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ANTIPARKINSONIAN DRUGS - Coggle Diagram
ANTIPARKINSONIAN DRUGS
LEVADOPA
DOPAMINE PREURSOR
ACT ON BOTH D1 AND D2 RECEPTORS OF STRIATUM
STIMULATE EXCITATORY D1
STIMULATE INHIBITORY D2
SMOOTHENS MOVEMENTS
REDUCE MUSCLE TONE
ACTIONS
CNS
PARKINSONS
RESOLVE HYPOKINESIS AND RIGIDITY
LATER TREMOR IS RESOLVED
POSTURE
GAIT
HANDWRITING
SPEECH
FACIAL EXPRESSION
MOOD
SELF CARE AND INTEREST
GENERAL ALERTING RESPONSE
EXCITEMENT
FRANK PSYCHOSIS
INC SEXUAL ACTIVITY
CVS
DA
TACHY
CENTRAL ACTION
POSTURAL HYPOTENSION
CTZ
NAUSEA
VOMITING
ENDOCRINE
DA ACTS ON MAMMOTROPES
INHIBIT PROLACTIN RELEASE
DA ACTS ON SOMATOTROPES
INCREASE GH RELEASE
ADE
NAUSEA, VOMITING
POSTURAL HYPOTENSION
ARRHYTHMIA
ANGINA EXACERBATION
ALTERED TASTE SENSATION
AT INITIATION OF THERAPY
AFTER PROLONGED THERAPY
ABNORMAL MOVEMENTS
BEHAVIOURAL EFFECTS- PSYCHOSIS
DEGENERATING DA NEURONS
DA IS SYN IN STRIATUM IN A MOMENT-TO-MOMENT BASIS
FLUCTUATING MOTOR CONTROL
PERIPHERAL DECARBOXYLASE INHIBITORS
CARBIDOPA
BENSERAZIDE
BENEFITS
L DOPA T1/2 PROLONGED
SYSTEMIC CONC OF DA REDUCED
LESS NAUSEA, VOMIT
THERAPEUTIC LEVEL OF LDOPA ACHIEVED FASTER
ON-OFF EFFECT MINIMISED
IMPROVEMENT
CARDIAC COMPLICATIONS REDUCED
PYRIDOXINE REVERSAL OF DOPA DOES NOT TAKE PLACE
COMT INHIBITORS
ENTACAPONE, TOLCAPONE
PERIPHERAL METAB OF LDOPA TO 3-OMD IS INHIBITED
DEC 3-OMD COMPETITION FOR ENTRY INTO BBB
RECREASE COMT ACTION IN BRAIN ALSO
SMOOTHENS "WEARING OFF"
ADE
YELLOW ORANGE DISCOLORATION OF URINE
LATE THERAPY IN ADVANCED STAGES OF PD
SELECTIVE MAO-B INHIBITOR
SELEGILINE
ADV
INTRACEREBRAL DEGRADATION OF DA IS RETARDED
ATTENUATES MOTOR FLUCTUATIONS
DISADV
ADVANCED CASES OF ON-OFF EFFECT , DYSKINESIAS ARE NOT IMPROVED
METABOLIZE TO AMPHETAMINE
INSOMNIA, AGITATION
RASAGILINE- NEUROPROTECTIVE
EARLY THERAPY
DOPAMINERGIC AGONISTS-- D2/D3
ROPINIROLE
PRAMIPEXOLE
ADV
SLOWER RATE OF NEURONAL DEGRADATION
LESS DYSKINESIA
LESS MARKED ON-OFF EFFECT
DISADV
PSYCHIATRIC S/E MORE COMMON
CENTRAL ANTICHOLINERGICS
REDUCING UNBALANCED CHOLINERGIC ACTIVITY
TREMOR IS BENEFITTED 1ST
HYPOKINESIA IMPROVES THE LEAST
SIALORRHEA IS CONTROLLED
INEXPENSIVE, LESS S/E
EFFECTIVE IN DRUG INDUCED PD
S/E
MEMORY AND COGNITION IMPAIRED
BLURRED VISION
URINARY RETENTION