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Phosphorylation of ITAM, Co-stimulation (CD28 on T cells), Co receptor CD4…
Phosphorylation of ITAM
ZAP-70
LAT
GADP5
SLP-76
Co-stimulation (CD28 on T cells)
PI-3 kinase
PIP3
PLC gamma
Active form of PLC gamma
PIP2
IP3
Ca+2 channels open
Opening of CRAC channels
Increased Ca+2 levels
Activation of calcineurin
2 more items...
DAG
PKC-Omega
Activates JNK
Phosphorylates CARMA1
+BcL10 +MALT1
1 more item...
RAS
AP-1
Also recruits
Akt (cell survival)
Phosphorylates
Co receptor CD4
Lck
CD3
Phosphorylated by GSK3 & CK2
Inactive NFAT
BcR
Ig alpha, beta
CD21 (CR2) + CD19 + CD81 (TAPA-1)
The B- cell co-receptor complex
Binding of CD21 to C3d-tagged antigens
Co-ligation of co receptor
phosphorylate CD19
Binds to Src family tyrosine kinase
TCRs