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Phosphorylation of ITAM, Co-stimulation (CD28 on T cells), Co receptor CD4…

- - - - Active form of PLC gamma
        
        PIP2
        
        IP3
        
        Ca+2 channels open
        
        Opening of CRAC channels
        
        Increased Ca+2 levels
        
        Activation of calcineurin
        
        2 more items...
        
        DAG
        
        PKC-Omega
        
        Activates JNK
        
        Phosphorylates CARMA1
        
        +BcL10 +MALT1
        
        1 more item...
        
        RAS
        
        AP-1
    - - Akt (cell survival)
- - - - phosphorylate CD19
        
        Binds to Src family tyrosine kinase

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Phosphorylation of ITAM

Co-stimulation (CD28 on T cells)

ZAP-70

LAT

SLP-76

GADP5

Co-stimulation (CD28 on T cells)

PI-3 kinase

PIP3

PLC gamma

TCRs

Co receptor CD4

Lck

Phosphorylates

Active form of PLC gamma

Also recruits

Akt (cell survival)

PIP2

IP3

DAG

Ca+2 channels open

Opening of CRAC channels

PKC-Omega

RAS

CD3

Increased Ca+2 levels

Activation of calcineurin

Activated NFAT

Phosphorylated by GSK3 & CK2

Inactive NFAT

Cyclosphorin A (Inhibitor of clcineurin)

Activates JNK

Phosphorylates CARMA1

+BcL10 +MALT1

TAF-6

TAK-1

IKK gamma (NEMO), alpha, beta

Phosphorylates IkB

NfKb activation

IL-2 production

AP-1

BcR

Ig alpha, beta

CD21 (CR2) + CD19 + CD81 (TAPA-1)

The B- cell co-receptor complex

Binding of CD21 to C3d-tagged antigens

Co-ligation of co receptor

phosphorylate CD19

Binds to Src family tyrosine kinase